A New Geldanamycin Analogue from Streptomyces hygroscopicus
| 作 者：Hao Zhang, Guang-Zhi Sun, Xiang Li, Hong-Yu Pan*, Yan-Sheng Zhang* |
| 刊物名称：Molecules |
| 出版年份：2010 |
| 卷：15 |
| 期：3 |
| 页码：1161-1167 |
论文摘要：
A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23).
